![]() A genome-wide association study revealed that a common inherited polymorphism in the TCL1A promoter was associated with a slower expansion rate in clonal haematopoiesis overall, but the effect varied by driver gene. We applied this method to 5,071 people with clonal haematopoiesis. ![]() Here, to circumvent this limitation, we developed a method to infer the expansion rate from data from a single time point. These lesions are precursors for blood cancers 2-6, but the basis of their fitness advantage remains largely unknown, partly owing to a paucity of large cohorts in which the clonal expansion rate has been assessed by longitudinal sampling. Mutations in a diverse set of driver genes increase the fitness of haematopoietic stem cells (HSCs), leading to clonal haematopoiesis 1. NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium Thomas W Blackwell ![]()
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